ARTEFILL is the first and only FDA-approved permanent wrinkle filler for the correction of smile lines. Before your initial treatment with ARTEFILL, a skin test must be administered 4 weeks prior to screen for an allergy to the product. In addition to the skin test, expect 2 treatments to be required when choosing ARTEFILL. Results from ARTEFILL continue to improve over the course of several months and stand the test of time.